Morning Sickness Timeline: When It Starts, Peaks & Ends

Typical Morning Sickness Course

• Onset: ~6 weeks LMP (4 weeks post-conception); range 4–7 weeks.
• Peak: Weeks 8–12 (highest hCG levels).
• Resolution: Most improve by 14–16 weeks; ~10–20% persist into 2nd trimester; rare cases last until delivery.

Variability Factors

• Multiples pregnancy → earlier, more severe
• History of motion sickness/migraines
• Genetic predisposition (GDF15 sensitivity)

Management

• Small, frequent meals; protein-rich snacks
• Ginger (tea, chews, 250 mg 4× daily)
• Vitamin B6 (25 mg 3× daily) ± doxylamine (Unisom)
• Hydration, rest, avoid triggers
• Prescription options (ondansetron, metoclopramide) if severe

Red Flags (Hyperemesis Gravidarum)

Weight loss >5%, ketonuria, dehydration, inability to tolerate fluids → IV fluids, hospitalization.