Premarin: Uses, Side Effects & Information for Women & Teens

Premarin is an estrogen replacement drug. It̵7;s available as a tablet or topical cream. Premarin̵7;s primary uses include reducing menopausal symptoms, boosting maturity for slow-developing teenagers and lessening the effects of some forms of prostate and breast cancer. For younger females, physicians can prescribe Premarin cream for vaginal irritation. It̵7;s a common treatment for young girls 3 months to 6 years old, for labial adhesions (when the labial skin around the vagina sticks together). The North American Society for Pediatric and Adolescent Gynecology (NASPAG) warns that ̶0;estrogen preparations may occasionally cause side effects, especially if used for prolonged periods longer than a few weeks.̶1;

Breast Budding

• Using estrogen cream for a prolonged time, more than eight weeks, in young girls can cause small amounts of breast development or other signs of puberty. According to an article on labial adhesions on the Keep Kids Healthy website, breast budding isn̵7;t ̶0;common with the short time of treatment recommended ̷0; especially if you are sure to concentrate the cream on the area of the adhesion and avoid other skin surfaces.̶1;

  The site also advises the applier of the cream to wash her hands after treatment to ensure the Premarin isn̵7;t accidentally applied elsewhere on the toddler. If you do notice breast development, you should stop using the cream immediately. The budding will go away after discontinuation of the cream.

Irritation

• Applying Premarin to the skin can cause various forms of irritation, even if it̵7;s only applied within the suggested time frame. Skin irritation will focus around the treatment area. It can include vaginal itching or mild vaginal burning.

  The Premarin website also warns against inflammation of the vagina. Rashes and hives are considered a severe allergic reaction to the cream; stop application and seek medical attention immediately if you see these adverse effects.

Vaginal Bleeding

• Premarin treatment can cause vaginal spotting or breakthrough bleeding. According to NASPAG, this effect most often occurs when the cream treatment ends. The effect will stop on its own eventually.

Bloating

• Premarin can encourage fluid retention. This retention can cause bloating and swift weight changes. While this side effect is unlikely for toddlers, the drug should be used with caution if the child has kidney or heart problems, as these can be affected by excess fluid.