Dermatix Ultra for Scars and Stretch Marks: Indications and Evidence

Dermatix Ultra is a topical silicone gel formulation (polysiloxane + vitamin C ester) indicated for scar management.

Approved Indications

• Hypertrophic Scars & Keloids: From surgery (general, plastic, burn, traumatic), pediatric procedures. Flattens, softens, reduces erythema, pruritus.
• Atrophic Acne Scars (Face): Improves appearance of depressed scars via hydration and collagen modulation.

Mechanism

• Silicone: Occlusive hydration → normalizes keratinocyte signaling → reduces fibroblast stimulation → less collagen deposition.
• Vitamin C ester (ascorbyl tetraisopalmitate): Antioxidant, promotes collagen synthesis, lightens hyperpigmentation.

Usage

• Apply thin layer 2× daily to clean, dry scar.
• Allow to dry (1–2 min); can apply sunscreen/makeup over.
• Minimum 60–90 days for mature scars; 12+ weeks for new scars.
• Sheets (Dermatix Clear) available for larger areas.

Evidence

• Silicone gel/sheeting: Level 1 evidence for hypertrophic scar/keloid prevention and treatment (international guidelines).
• Vitamin C ester: Limited specific trials in combination; theoretical synergy.

Limitations

• Not for open wounds.
• Less effective for mature, wide, or contracture scars.
• Stretch marks (striae distensae): Silicone may improve texture/color but does not eliminate dermal tears. Retinoids, microneedling, laser more effective.

Cost & Access

OTC in many countries; ~$30–50/tube (15g). Prescription in some regions.

Silicone is the gold standard topical for abnormal scarring. Dermatix Ultra adds vitamin C for pigmentation.