The Dermis: Structure and Function of the Skin's Middle Layer

The dermis is the thick, vascular, connective tissue layer between the epidermis and hypodermis (subcutis).

Composition

  • Papillary dermis (superficial): Loose areolar CT, dermal papillae (interlock with epidermis), capillaries, Meissner's corpuscles (light touch).
  • Reticular dermis (deep): Dense irregular CT, thick collagen/elastin bundles, hair follicles, sebaceous/sweat glands, Pacinian corpuscles (deep pressure), blood/lymph vessels, nerves.

Key Functions

  • Structural support, elasticity, tensile strength
  • Thermoregulation (vasodilation/constriction, sweating)
  • Sensation (touch, pressure, pain, temperature)
  • Nutrient supply to avascular epidermis
  • Immune surveillance (dermal dendritic cells, mast cells)
  • Appendage housing (hair, nails, glands)

Clinical Relevance

Wound healing (granulation tissue = new dermis), aging (collagen/elastin loss), scarring (dermal repair), dermatoses (psoriasis, eczema, neoplasia).

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