Seronegative Rheumatoid Arthritis: Symptoms, Diagnosis, and Treatment
Seronegative rheumatoid arthritis (RA) lacks the typical autoantibodies (rheumatoid factor, anti-CCP). It accounts for 10–20% of RA cases, is more common in men, and tends to onset later than seropositive RA.
Symptoms mirror seropositive RA: joint pain, stiffness, swelling, inflammation. However, disease course may be milder with less joint damage.
Diagnosis relies on symptoms, physical exam, blood tests to rule out other conditions, and imaging (X-ray, MRI) to assess joint damage.
Treatment mirrors seropositive RA: medications for pain, inflammation, and slowing disease progression.
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