hCG Shelf Life: Storage, Stability & Brand-Specific Expiration

hCG (hCG) Product Stability & Storage Guidelines

hCG shelf life varies significantly by formulation, brand, and storage conditions. Always defer to manufacturer labeling.

Brand Examples (Illustrative)

• Ovidrel (choriogonadotropin alfa, prefilled syringe): 30 months (2.5 years) refrigerated
• Pregnyl (urinary hCG, lyophilized powder): 36 months (3 years) refrigerated; 28 days after reconstitution
• Novarel (urinary hCG, lyophilized): Similar to Pregnyl
• Generic/compounded: Highly variable; often shorter

Storage Requirements

• Refrigerate 2–8°C (36–46°F) – do NOT freeze
• Protect from light (amber vial/box)
• After reconstitution (lyophilized): Use within hours (per label) or ≤28 days refrigerated
• Prefilled pens/syringes: Single-use; discard after dose

Stability Risks

• Temperature excursions → aggregation, potency loss
• Freezing → protein denaturation
• Light exposure → oxidation
• Repeated needle punctures (multi-dose vials) → contamination

Clinical Guidance

1. Check expiration date on every vial/syringe
2. Inspect: No particulate, discoloration, clumping
3. If storage compromised → discard; do not use
4. Travel: Insulated cooler with temp monitor; carry-on only
5. Contact pharmacy/manufacturer if uncertain

hCG is a glycoprotein hormone—fragile. Proper cold chain is non-negotiable for efficacy and safety.