Cardiac vs. Skeletal Muscle: Structural and Functional Differences

FeatureCardiac MuscleSkeletal Muscle
LocationHeart only (myocardium)Attached to skeleton
ControlInvoluntary (autonomic)Voluntary (somatic)
Cell ShapeBranched, short, cylindricalLong, cylindrical, multinucleated
NucleiSingle, centralMultiple, peripheral
StriationsYes (sarcomeres)Yes
Intercalated DiscsYes (gap junctions + desmosomes)No
ContractionRhythmic, automatic (pacemaker)Phasic, neural stimulation
Fatigue ResistanceHigh (mitochondria-rich, aerobic)Variable (fiber type dependent)

These differences reflect the heart's need for continuous, coordinated pumping vs. skeletal muscle's role in voluntary movement.

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