Hand, Foot, and Mouth Disease: Cause of Flaky Skin on Hands and Feet

Flaky skin on hands/feet is a classic sign of Hand, Foot, and Mouth Disease (HFMD), a viral illness common in young children.

Cause

Enteroviruses—mainly Coxsackievirus A16 and Enterovirus 71. Spread via saliva, mucus, stool, contaminated surfaces.

Symptoms & Course

• Fever (100–104°F)
• Sore throat, difficulty swallowing
• Red bumps → blisters on hands, feet, mouth; may spread to buttocks/genitals
• Resolves in 7–10 days

Rare complications: dehydration, meningitis, encephalitis.

Treatment

Supportive: rest, fluids, acetaminophen/ibuprofen for pain. Severe cases may need hospitalization.

Prevention

• Frequent handwashing
• Avoid contact with sick individuals
• Disinfect shared objects

EV71 vaccine exists in some countries but not routinely recommended in the US.

More info: CDC HFMD page.