How are the mechanisms of action frusemide and losartan in treating hypertension different?

Furosemide (Lasix) is a loop diuretic that inhibits the reabsorption of sodium and chloride ions in the loop of Henle, leading to increased urine output and decreased blood volume. This reduction in blood volume decreases the pressure exerted on the blood vessel walls, lowering blood pressure.

Losartan (Cozaar) is an angiotensin II receptor blocker (ARB) that blocks the binding of angiotensin II, a hormone that causes blood vessels to constrict, to its receptors. This blockade prevents the constriction of blood vessels, leading to decreased peripheral vascular resistance and lower blood pressure.

In summary, furosemide works by increasing urine output and decreasing blood volume, while losartan works by blocking the constriction of blood vessels. Both medications are effective in treating hypertension, but they have different mechanisms of action.