Pseudogout: Causes, Risk Factors, and Symptoms

Pseudogout results from calcium pyrophosphate dihydrate (CPPD) crystal deposition in joints. Crystals form due to excess calcium or pyrophosphate, or low joint fluid pH.

Risk Factors

• Age: Most common in people over 65.
• Medical conditions: Hypothyroidism, hyperparathyroidism, hemochromatosis.
• Joint injury or surgery: Can trigger attacks.
• Medications: Diuretics and corticosteroids may increase risk.
• Genetics: Rarely, a genetic disorder can cause pseudogout.

Symptoms

Symptoms include sudden joint pain, swelling, warmth, and stiffness, often affecting knees, wrists, or ankles.