Gonorrhea Transmission: Risk Factors & Prevention

Neisseria gonorrhoeae infects mucosal surfaces of the reproductive tract, rectum, pharynx, and eyes. Transmission occurs via:

  • Unprotected sexual contact: Vaginal, anal, oral sex (giving/receiving).
  • Perinatal: Mother to neonate during vaginal delivery → ophthalmia neonatorum.
  • Autoinoculation: Genital to eye (rare).

Risk Factors

  • Multiple or new partners.
  • Inconsistent condom use.
  • Prior STI (marker for risk behavior).
  • Age 15–24 (highest incidence).
  • MSM (men who have sex with men): Higher rectal/pharyngeal rates.
  • Substance use (impaired judgment).

Prevention

  • Condoms (latex/polyurethane) for all penetrative/oral sex.
  • Regular screening (NAAT urine/swab) per CDC guidelines.
  • Partner notification/treatment (expedited partner therapy where legal).
  • Doxycycline PEP (200 mg within 72 hrs post-exposure) emerging for high-risk MSM.

Asymptomatic infection is common (especially pharyngeal/rectal/female genital)—screening detects silent carriers.

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