Bovine Spongiform Encephalopathy (BSE): Mortality and Understanding
BSE (mad cow disease) is a fatal prion disease in cattle. Mortality ≈100%. Caused by misfolded prion protein accumulating in brain/spinal cord, causing neurodegeneration.
First identified UK 1986; global spread followed. Strict controls (feed bans, surveillance) have drastically reduced cases.
Human Risk
Variant Creutzfeldt-Jakob disease (vCJD) from BSE-contaminated beef. Also ~100% fatal but extremely rare (~200 cases worldwide).
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