Hyperintense Signal on MRI: Definition and Clinical Context
In MRI, hyperintense means a region appears brighter (higher signal intensity) than surrounding tissue on a given sequence.
Sequence-Dependent:
- T1-weighted: Fat, blood products (methemoglobin), protein-rich fluid, melanin, gadolinium enhancement.
- T2-weighted / FLAIR: Edema, inflammation, demyelination (MS plaques), infarct (subacute/chronic), tumors, CSF.
- DWI (Diffusion-Weighted): Acute infarct (restricted diffusion), abscess, highly cellular tumors.
Interpretation requires correlation with clinical history, other sequences, and often contrast enhancement. "Hyperintense" is a description, not a diagnosis.
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