Typhoid & Paratyphoid Fever Treatment: Medications & Options

For Typhoid fever caused by Salmonella Typhi (Typhi O):

First-line treatment:

- Ceftriaxone (Rocephin)

- Azithromycin (Zithromax)

- Ciprofloxacin (Cipro)

- Ofloxacin (Floxin)

- Levofloxacin (Levaquin)

Alternative treatments:

- Cotrimoxazole (Bactrim, Septra)

- Amoxicillin-clavulanate (Augmentin)

- Piperacillin-tazobactam (Zosyn)

- Imipenem-cilastatin (Primaxin)

- Meropenem (Merrem)

For Paratyphoid fever caused by Salmonella Paratyphi A, B, or C (Typhi H):

First-line treatment:

- Ceftriaxone (Rocephin)

- Azithromycin (Zithromax)

- Ciprofloxacin (Cipro)

- Ofloxacin (Floxin)

- Levofloxacin (Levaquin)

Alternative treatments:

- Cotrimoxazole (Bactrim, Septra)

- Amoxicillin-clavulanate (Augmentin)

- Piperacillin-tazobactam (Zosyn)

- Imipenem-cilastatin (Primaxin)

- Meropenem (Merrem)

The specific antibiotic chosen will depend on the individual patient's clinical condition and antibiotic susceptibility testing results. It is important to complete the full course of antibiotics as prescribed to prevent relapse.