Bicuspid Aortic Valve Tissue Composition: Three-Layered Structure
The bicuspid aortic valve (BAV) consists of dense irregular connective tissue rich in collagen and elastin fibers.
Leaflet Layers (from blood-facing to aortic side)
- Endothelial layer (ventricularis): Single squamous cells; non-thrombogenic surface.
- Connective tissue core (fibrosa/spongiosa): Collagen (tensile strength), elastin (recoil), proteoglycans (hydration).
- Smooth muscle cell layer (aortic side): Contributes to valve tone and remodeling.
This trilaminar architecture provides durability for ~3 billion lifetime cycles. BAVs have abnormal collagen/elastin organization, predisposing to stenosis, regurgitation, and aortopathy.
Open Heart Surgery - Related Articles
- What is the fetal vessel that connects the pulmonary artery to the descending thoracic aorta?
- The Four Heart Valves: Mitral, Aortic, Pulmonary, and Tricuspid
- Valve Lead Explained: Engine Timing for Optimal Performance
- Becoming a Vascular Surgeon: Education Timeline, Fellowship & Career Outlook
- Pumps in Heart-Lung Machines: Centrifugal vs. Roller Pumps
- Heart Anatomy: Mediastinum, Pericardium & Anatomical Landmarks
- Disability Benefits During Heart Surgery Leave: A Guide for Employees