Tizanidine and Surgery: Preoperative Discontinuation Recommendation
Recommendation
Do not take tizanidine within 7–10 days before surgery.
Reason
Tizanidine is a centrally acting alpha-2 adrenergic agonist (muscle relaxant) that can cause hypotension and bradycardia, complicating anesthesia induction and intraoperative hemodynamic management.
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