Could there be any problem in conception for the second time if mother is Rh negative father positive and first pregnancy was terminated after forty five days of conception?

Yes, there could potentially be a problem in conception for the second time if the mother is Rh negative and the father is Rh positive, especially if the first pregnancy was terminated after 45 days of conception. This is because of a condition called Rh incompatibility.

When a Rh-negative mother carries a Rh-positive fetus, her immune system can recognize the Rh factor on the fetus's red blood cells as foreign and produce antibodies against it. These antibodies are called anti-Rh antibodies. If the anti-Rh antibodies cross the placenta and enter the fetal circulation, they can attach to the Rh-positive red blood cells and cause them to break down, leading to a condition called hemolytic anemia in the fetus.

In a subsequent pregnancy, if the father is again Rh positive, the mother's anti-Rh antibodies from the previous pregnancy may still be present in her bloodstream. These antibodies can cross the placenta and attack the Rh-positive red blood cells of the second fetus, causing hemolytic anemia even earlier and more severely. This can lead to complications such as miscarriage, stillbirth, or severe anemia in the newborn baby.

To prevent this problem, Rh-negative mothers who are pregnant with Rh-positive babies are given a medication called RhoGAM (Rh immunoglobulin). RhoGAM is an antibody that binds to any Rh-positive red blood cells that may have crossed the placenta and prevents the mother's immune system from producing its own anti-Rh antibodies. This helps to protect future Rh-positive fetuses from hemolytic anemia.

Therefore, if you are a Rh-negative mother and have had a previous pregnancy that was terminated after 45 days of conception, it is important to discuss your Rh status with your doctor and receive appropriate medical care to prevent any complications in future pregnancies.