Duphaston (Dydrogesterone) in Pregnancy: Risks, Indications, and Current Evidence

Duphaston (dydrogesterone) is a synthetic progestogen used for luteal support, threatened miscarriage, and menstrual disorders.

Pregnancy Use

• Indicated: Luteal phase support in ART, threatened miscarriage with documented progesterone deficiency, recurrent pregnancy loss (selected cases).
• Not for routine use in uncomplicated pregnancy.

Safety Data

• Large cohort studies (including >2,000 exposures) show no increased risk of congenital malformations vs. general population.
• No consistent signal for neural tube defects, cleft palate, or cardiac defects.
• Classified as FDA Category B (animal studies no risk; no adequate human studies — but extensive post-marketing data reassuring).

Contradiction Note

Original text claimed increased birth defects, ectopic pregnancy, miscarriage risk. Current evidence does not support these risks. Dydrogesterone is widely used in early pregnancy in many countries with favorable safety profile.

Clinical Guidance

• Use only with clear indication (proven deficiency, ART, recurrent loss).
• Dose: typically 10–20 mg/day orally.
• Discontinue once placental progesterone production established (~10–12 weeks).
• Always under medical supervision.

Discuss risks/benefits with your OB/GYN. Do not self-medicate.