Understanding Serum pH Regulation: Role of Lungs and Kidneys

The respiratory center of the medulla oblongata, which regulates the rate and depth of ventilation. As long as ventilation is normal, arterial PCO2 and thus serum pH is kept constant

The kidneys, which conserve of excrete the products of acid – base metabolism, including HCO3-,H,Na+ and k + through complex and adaptive mechanism