Methadone and Excedrin Migraine: Risks & Interactions - Expert Advice

Methadone is a potent opioid analgesic used to treat severe pain and opioid addiction. Excedrin Migraine is a brand-name medication that combines acetaminophen, aspirin, and caffeine. Acetaminophen is a pain reliever and fever reducer. Aspirin is an anti-inflammatory and pain reliever. Caffeine is a stimulant.

While methadone and Excedrin Migraine can both be used to relieve pain, they should not be taken together without first talking to a doctor. Methadone can interact with Excedrin Migraine, increasing the risk of side effects such as drowsiness, dizziness, and nausea. In some cases, methadone and Excedrin Migraine can also cause serious side effects such as respiratory depression and seizures.

If you are taking methadone and are considering taking Excedrin Migraine, talk to your doctor first to make sure it is safe for you. Your doctor can recommend the best way to take these medications together and can monitor you for any side effects.