What would cause metabolic alkalosis to slide into acidosis?

1. Loss of bicarbonate: Bicarbonate is an important base in the body that helps to maintain the pH of the blood. If there is a loss of bicarbonate, such as through vomiting or diarrhea, the blood can become more acidic, leading to acidosis.

2. Increased production of acids: Certain conditions can cause the body to produce more acids, such as diabetic ketoacidosis or lactic acidosis. These acids can build up in the blood, leading to acidosis.

3. Reduced excretion of acids: The kidneys play an important role in excreting acids from the body. If the kidneys are not functioning properly, such as in renal failure, the acids can build up in the blood, leading to acidosis.

4. Administration of certain medications: Some medications, such as diuretics or carbonic anhydrase inhibitors, can cause metabolic alkalosis to slide into acidosis.

5. Sepsis: Sepsis is a severe infection that can lead to a variety of complications, including metabolic alkalosis and acidosis.