| | Conditions & Treatments | Lupus When do leptospirosis symptoms start? The incubation period for leptospirosis, which is the time between exposure to the bacteria and the appearance of symptoms, varies from 2 to 30 days. In most cases, symptoms appear within 10 days after exposure. Lupus - Related Articles Does systemic lupus erythematosus produce a rash? Lupus and Leg Pain What is roxidolin? How is opsonization associated with inflammation? What system affect the lupus erythematosus? What does lupus do to the skin? What is the causative agent of leptospirosis?