Antibiotics for Plague (Black Death): Treatment Options & Effectiveness

The antibiotics that can cure the plague (black plague) includes: Tetracycline, streptomycin, chloramphenicol and sulphonamides, or more commonly doxycycline and gentamicin. There are other antibiotics which are also effective (e.g. fluoroquinolones and trimethoprim).

Early administration of appropriate antibiotics greatly reduces the risk of the plague evolving into the septicaemic or pulmonary form of disease: streptomycin is the drug of choice.