| | Conditions & Treatments | Hormonal Disorders Which organ in boys increases and enlarge hormone production during puberty? The main reproductive organ that increases and undergoes notable development in boys during puberty is the testes. Hormonal Disorders - Related Articles How to Naturally Build Testosterone Cushing's Disease Definition Adrenal Disease Symptoms Recovering From Adrenal Fatigue Been taking Mensovit Plus for one month after sex have not got my period Does it prevent pregnancy? Testosterone & Beard Growth Hormone Therapy for Men