Does depakote over time make you sterile?

There is no evidence to suggest that taking Depakote (sodium valproate) over time leads to sterility or impairs fertility. Studies have found that Depakote does not affect sperm count, motility, or morphology in men. However, it is important to note that Depakote crosses the placenta and can reach the fetus during pregnancy, and there is a risk of birth defects if Depakote is taken during the first trimester.

If you have concerns about the effects of Depakote on your fertility or are considering pregnancy, it is recommended to discuss this with your doctor for personalized advice and to weigh the risks and benefits of continued treatment.