Herpes Virus Family: Clinical Manifestations by Virus Type
Eight human herpesviruses cause distinct syndromes:
| Virus | Primary Syndrome | Typical Sites |
|---|---|---|
| HSV-1 | Oral herpes (cold sores) | Lips, mouth, face; can cause genital herpes via oral-genital contact |
| HSV-2 | Genital herpes | Genitals, perineum, buttocks |
| VZV | Chickenpox (primary); Shingles (reactivation) | Chickenpox: generalized; Shingles: single dermatome |
| EBV | Infectious mononucleosis | Pharynx, lymph nodes, spleen, liver |
| CMV | Mononucleosis-like; congenital infection | Multiple organs (fetus); salivary glands, lungs (immunocompromised) |
| HHV-6/7 | Roseola (exanthem subitum) | Generalized rash after fever defervescence |
| KSHV (HHV-8) | Kaposi sarcoma, primary effusion lymphoma | Skin, lymph nodes, viscera (HIV/immunosuppressed) |