Is it true that about 3 liters of fluid are lost to the tissue spaces every 24 hours and returned blood stream as lymph?
No, it is not true.
Explanation:
The volume of fluid filtered from the capillaries each day is about 20 liters, and all but about 3 liters of this is returned directly to the blood by the small venules. The 3 liters that do not return directly to the blood are returned via the lymphatic system, which is why the lymphatic system sometimes is called a third circulation, in addition to the pulmonary and systemic circulations.
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