Sickle Cell Trait Inheritance: Does It Skip Generations?

No, sickle cell trait cannot skip a generation. Sickle cell trait is an autosomal dominant condition, which means that a person only needs one copy of the sickle cell gene to have the trait. If a person has sickle cell trait, they will always pass on the sickle cell gene to their children, even if the child does not have sickle cell trait themselves.