What causes mutation from cri du chat syndrome?

The most common cause of Cri du Chat syndrome is a deletion, or loss, of genetic material from the short arm of chromosome 5 (5p). This deletion can occur either spontaneously or as a result of a chromosomal translocation. In cases of spontaneous deletion, the genetic material is lost during cell division. In cases of translocation, the genetic material from chromosome 5 is transferred to another chromosome, resulting in a loss of genetic material from chromosome 5.

The size of the deletion can vary, and larger deletions are associated with more severe symptoms of Cri du Chat syndrome. The deletion can also affect different genes, which can lead to different symptoms. In addition to the deletion, other chromosomal abnormalities, such as duplications or inversions, can also cause Cri du Chat syndrome. These abnormalities are much less common than the deletion.