What is stage 4 Rett syndrome?

Stage 4: Severe Motor Impairment (Late Childhood or Adult)

* Often begins in late childhood, characterized by severe motor impairment

* Decreased purposeful hand use

* Increased rigidity and contractures of the limbs and trunk

* Abnormal breathing patterns

* Gastrointestinal disturbances

* Scoliosis (spine curvature)

* Seizures

* Communication abilities may deteriorate

* May experience periods of screaming or crying

It is important to note that the progression of symptoms and the severity of Rett syndrome can vary greatly from person to person.