Which malignant melanoma patients are at high risk of recurrence?

Patients with malignant melanoma are at higher risk of recurrence if they have certain characteristics. These include:

1. Breslow thickness: This is a measure of the depth of the melanoma. The thicker the melanoma, the higher the risk of recurrence.

2. Clark level: This is a measure of how deeply the melanoma has invaded the skin. The higher the Clark level, the higher the risk of recurrence.

3. Ulceration: This is a break in the skin over the melanoma. Ulceration is a sign that the melanoma is more aggressive and is more likely to recur.

4. Mitosis count: This is a measure of how quickly the melanoma cells are dividing. A high mitosis count is a sign that the melanoma is more aggressive and is more likely to recur.

5. Lymphovascular invasion: This is the presence of melanoma cells in the lymphatic or blood vessels. Lymphovascular invasion is a sign that the melanoma has spread and is more likely to recur.

6. Regional lymph node involvement: This is the presence of melanoma cells in the regional lymph nodes. Regional lymph node involvement is a sign that the melanoma has spread and is more likely to recur.

7. Distant metastases: This is the presence of melanoma cells in distant parts of the body, such as the lungs or liver. Distant metastases are a sign that the melanoma is advanced and is more likely to recur.

8. BRAF mutation: This is a mutation in the BRAF gene that is found in some melanomas. The BRAF mutation is associated with a higher risk of recurrence.

9. Younger age: Patients who are younger at the time of diagnosis are more likely to have a recurrence than older patients.

10. Male gender: Men are more likely to have a recurrence than women.

11. Immune system suppression: Patients who have a weakened immune system are more likely to have a recurrence.