| | Cancer | Skin Cancer What is the origin of melanoma? The main type of melanoma arises from the pigment cells (melanocytes) in the skin. The melanocytes are most commonly found in the epidermis, the outermost skin layer. Skin Cancer - Related Articles Melanoma Skin Cancer Treatments Early Stages of Melanoma Description of Malignant Melanoma What affects eczema? Common Types of Skin Cancer Late Stage Skin Cancer Symptoms How do you know if it is fatty tissue or a lump on the back of your