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MHC Expression on B Lymphocytes: MHC-II Only

B lymphocytes express MHC class II constitutively (professional antigen-presenting cells). They do not express MHC class I under normal conditions.

MHC Distribution

B Cell Specifics

Constitutive MHC-II → present antigen to CD4+ T follicular helper (Tfh) cells → germinal center reaction, class switching, affinity maturation.
MHC-I induced by IFN-γ (inflammation), but not baseline.
Co-stimulation: CD80/86 (B7) binding CD28 on T cells.

Defects: Bare lymphocyte syndrome (MHC-II deficiency) → severe immunodeficiency.

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MHC Class	Expression	Function
MHC-I	All nucleated cells	Present endogenous peptides to CD8+ T cells (cytotoxic)
MHC-II	Professional APCs: B cells, dendritic cells, macrophages, thymic epithelium	Present exogenous peptides to CD4+ T cells (helper)