Myeloblasts: Understanding Early Bone Marrow Cells

Myeloblast

Myeloblasts are the earliest recognizable cells in the myeloid lineage. They are large, round cells with a high nuclear-to-cytoplasmic ratio. The nucleus is round or oval with fine chromatin and one or two prominent nucleoli. The cytoplasm is basophilic and contains a few azurophilic granules.

Myeloblasts are derived from hematopoietic stem cells in the bone marrow. They proliferate and differentiate into more mature myeloid cells, including promyelocytes, myelocytes, metamyelocytes, and mature neutrophils.

Myeloblasts can be found in the bone marrow and peripheral blood. An increased number of myeloblasts in the peripheral blood is a sign of leukemia or other myeloproliferative disorder.