Demerol (Meperidine) Administration: IV vs. IM Routes
Intravenous (IV) – rapid onset (minutes); used for acute severe pain, titration in monitored settings. Risk: respiratory depression, hypotension.
Intramuscular (IM) – slower absorption (peak 30–60 min); alternative when IV access unavailable. Preferred for prehospital or brief procedures.
Note: Meperidine is less favored today due to neurotoxic metabolite (normeperidine) accumulation, especially with repeated dosing or renal impairment. Alternatives (morphine, hydromorphone, fentanyl) are generally preferred.
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