What do moles on the palm of your hand mean?

There is no scientific evidence to support any particular meaning or significance attributed to moles on specific parts of the body, including the palm of the hand.

Moles are generally caused by clusters of pigment-producing cells (melanocytes). They are common and usually harmless. If you have any concerns about a mole, such as if it suddenly changes in size, shape, or color, it is advisable to consult a dermatologist.