Diazepam and Cyclobenzaprine (Flexeril) Interaction: Risks and Dangers

Combining diazepam (a benzodiazepine) with cyclobenzaprine (brand name Flexeril) can be potentially dangerous. Both medications depress the central nervous system (CNS). Diazepam reduces CNS activity and can cause respiratory depression, while cyclobenzaprine may lower the seizure threshold and add to sedative effects. When taken together, their depressant effects are amplified, significantly increasing the risk of side effects such as severe drowsiness, dizziness, confusion, impaired coordination, and respiratory depression. In extreme cases, this combination can be fatal.

It is generally not recommended to use these medications concurrently without explicit medical supervision. Always consult a healthcare professional before combining any CNS depressants.