Shingles Vaccine & Knee Replacement: Is There a Risk?

No. The shingles vaccine is not a live virus vaccine and cannot affect knee replacements. The shingles vaccine is a recombinant vaccine, which means that it contains a piece of the virus that is responsible for causing shingles. This piece of the virus is not able to cause infection, but it can trigger the immune system to produce antibodies that protect against the virus.