Preventing Transplant Rejection: Immunosuppressive Drugs, HLA Matching, Pre-Transplant Conditioning, and Antibody Induction Therapy
Tissue rejection is the immune response to foreign tissue (e.g., organ transplant). Prevention strategies:
- Immunosuppression: Drugs suppressing immune system: corticosteroids, calcineurin inhibitors, mycophenolate mofetil.
- HLA matching: Donor-recipient genetic similarity reduces rejection risk (immune system less likely to recognize organ as foreign).
- Pre-transplant conditioning: Radiation/chemotherapy to weaken recipient's immune system pre-transplant.
- Antibody induction therapy: Antibodies targeting immune cells involved in rejection; for high-risk patients.
- Donor-specific transfusion: Pre-transplant donor blood transfusion exposes recipient to donor antigens, reducing rejection likelihood.
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