| | Mental Health | Depression What is the opposite of sad and not happy? The opposite of sad is happy. The opposite of not happy is sad. So, the opposite of sad and not happy is happy and sad. Depression - Related Articles Nighttime Depression How to Remove Skin Tags With Duct Tape What rate do Women experience depression compared to men? Depression: Are You Honest With Your Doctor? How to Change Negative Thoughts to Positive How to Find Alternatives to Antidepressants What Are the Signs and Symptoms of Depression?