| | Family Health | Teen Health What age do symptoms on MS most usually appear? The symptoms of multiple sclerosis (MS) usually appear between the ages of 20 and 40 years. However, MS can occur at any age, including childhood and adulthood. Teen Health - Related Articles What does a 17 hcg level mean? Therapy for Teens: What to Expect Why is a teen with an std less likely to seek medical attention than adult? How to Prevent Teen Obesity What is the order of puberty? How to Handle Teen Stress Symptoms of ADD in Teenagers