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Fetal Hematopoiesis: Liver, Spleen, and Bone Marrow Timeline
Blood cell production shifts during gestation:
- Liver: Primary site until ~3rd trimester; produces RBCs, WBCs, platelets.
- Spleen: Contributes RBCs and WBCs (mainly 2nd trimester).
- Bone marrow: Becomes primary site in 3rd trimester; continues throughout life.
This ontogeny explains why certain anemias or malignancies present differently in fetuses/neonates vs. adults.
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