Why Not to Crush Enteric-Coated, Sustained-Release & Immediate-Release Tablets

Enteric-Coated Tablets

Coating survives stomach acid, dissolves in small intestine (higher pH). Protects drug from degradation and stomach from irritation. Crushing destroys coating → premature release, reduced efficacy, gastric irritation.

Sustained/Extended-Release Tablets

Matrix/coating controls release over hours. Crushing causes dose dumping → sudden high concentration → toxicity risk, loss of prolonged effect.

Immediate-Release Tablets (Tablets for Solution)

Designed to dissolve in specified liquid before administration. Not for crushing—dissolve as directed for uniform distribution and absorption.

General Rule

Never alter solid dosage forms without pharmacist/prescriber approval. Ask about liquid alternatives if swallowing is difficult.