Acid Reflux Medication Price Comparison: OTC Antacids, H2 Blockers, and PPIs

Prices vary by retailer, region, and formulation. Below are approximate U.S. retail ranges (2024) for common OTC products.

Antacids (Immediate, Short Duration)

• Tums (calcium carbonate): 72 ct $5–7; 150 ct $8–10
• Rolaids (CaCO₃ + Mg(OH)₂): 60 ct $5–7
• Maalox/Mylanta liquid: 12 oz $6–9

H₂ Blockers (Onset 30–60 min, Duration 8–12 hrs)

• Famotidine 20 mg (Pepcid AC): 30 ct $8–12; 50 ct $12–16
• Cimetidine 200 mg (Tagamet): 30 ct $10–14

Proton Pump Inhibitors (PPIs) (Delayed onset, 24-hr coverage, 14-day course)

• Omeprazole 20 mg (Prilosec OTC): 14 ct $15–20; 28 ct $25–30; 42 ct $30–38
• Esomeprazole 20 mg (Nexium 24HR): 14 ct $20–26; 28 ct $35–42; 42 ct $45–55
• Lansoprazole 15 mg (Prevacid 24HR): 14 ct $16–22; 28 ct $30–38

Cost-Saving Tips

• Store brands (generic) = 30–50% cheaper, same active ingredient.
• Warehouse clubs (Costco, Sam’s) often lowest per-unit cost.
• Manufacturer coupons, pharmacy discount apps (GoodRx, SingleCare).
• PPIs: 14-day course ≠ maintenance; consult MD for long-term use.

Prices are estimates; verify at your pharmacy.