How Organic Acids Elevate Serum Uric Acid Levels: Mechanism and Examples

Certain organic acids increase serum uric acid by inhibiting urate secretion in the proximal tubule.

Examples

• Lactic acid
• D-lactic acid
• β-hydroxybutyrate (ketone body)
• Fructose and other sugars metabolized to lactate

This mechanism explains hyperuricemia in conditions like lactic acidosis, ketoacidosis, and high fructose intake.