Zoloft and Restless Legs Syndrome (RLS): Understanding the Connection

Though the exact causes of restless leg syndrome, a neurological disorder, are unclear, symptoms of the disorder are associated with a type of antidepressant drug that includes Zoloft.

Zoloft

• Zoloft is the brand name of a drug called sertraline. Zoloft is a selective serotonin reuptake inhibitor (SSRI) that may be prescribed by a doctor for the treatment of depression, anxiety, panic disorder, and obsessive-compulsive disorders, among other conditions.

RLS

• Restless leg syndrome, which may be referred to as RLS, is a condition characterized by painful, burning, or creeping sensations within the legs when the legs are at rest, making it difficult to sit still, sleep, and relax. Those with RLS may feel an urge to move their legs to relieve the unpleasant sensations.

Cause

• According to MayoClinic.com, often there is no identifiable cause of restless leg syndrome. According to HelpGuide.org, certain types of medications, including SSRIs, may trigger an onset of restless leg syndrome symptoms.

Side Effects

• According to MayoClinic.com, Zoloft may cause side effects akin to symptoms of restless leg syndrome, such as restlessness, muscle spasms, movement disorders, and an inability to remain still.

Treatment

• Mediacations that may be prescribed for the treatment of restless legs syndrome include opiods, anticonvulsants, and anti-anxiety drugs. Ropinirole is a drug approved by the Food and Drug Administration for the treatment of restless leg syndrome.