Terbinafine Rash: A Rare but Possible Side Effect

Rash is an uncommon (<1–2%) but recognized adverse effect of terbinafine (oral or topical).

Typical Presentation

• Mild, maculopapular eruption
• Usually appears within first few weeks
• Often resolves spontaneously or after discontinuation

Serious Cutaneous Reactions (Rare)

• Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN)
• Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
• Signs: Widespread blistering, mucosal involvement, fever, lymphadenopathy, organ involvement

Action Steps

1. Stop terbinafine and contact prescriber immediately if rash develops.
2. Do not restart without medical evaluation.
3. Seek emergency care for signs of severe reaction (blisters, mouth sores, fever, swelling).

Most rashes are benign, but serious reactions require prompt recognition.