Strep Throat and Rash: Typical Presentation and Differential

Streptococcal pharyngitis (Group A Strep) presents with:

  • Sudden sore throat, odynophagia.
  • Fever >38.3°C.
  • Tonsillar exudates, petechiae on palate.
  • Anterior cervical lymphadenopathy.
  • Absence of cough, rhinorrhea, hoarseness (suggests viral).

A rash on the buttocks/perineum is not typical. Consider:

  • Scarlet fever (sandpaper rash on trunk, flexures, face—circumoral pallor, strawberry tongue).
  • Viral exanthems (EBV, adenovirus, enterovirus).
  • Drug eruption (if antibiotics started).
  • Diaper/contact dermatitis (infants).

Confirm with rapid antigen test or throat culture. Treat with penicillin/amoxicillin × 10 days to prevent rheumatic fever.

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