Combining Norco & Tylenol Arthritis: Risks & Safety

It is not recommended to take Norco 5-325 and Arthritis Strength Tylenol together because they both contain acetaminophen, which can lead to liver damage if taken in high doses.

Norco 5-325 is a combination medication containing hydrocodone and acetaminophen. Hydrocodone is an opioid painkiller, and acetaminophen is a non-steroidal anti-inflammatory drug (NSAID). Arthritis Strength Tylenol is an over-the-counter pain reliever that contains acetaminophen.

Acetaminophen is the most common cause of liver failure in the United States. Taking too much acetaminophen can damage the liver, and the risk of liver damage increases when acetaminophen is taken with other medications containing acetaminophen.

If you are taking Norco 5-325, you should not take Arthritis Strength Tylenol or any other medications containing acetaminophen. If you have any questions about whether or not you can take a particular medication, you should talk to your doctor or pharmacist.