Suboxone and Opiate Rebound: How Long to Wait?

You should wait at least 24 hours after taking your last dose of Suboxone before using an opiate again. This is because Suboxone has a long half-life, and it can take up to 24 hours for the medication to completely leave your system. If you use an opiate too soon after taking Suboxone, you may experience withdrawal symptoms or other adverse effects.